Hesperus is an unincorporated community and a U.S. Post Office located in La Plata County, Colorado, United States. The Hesperus Post Office has the ZIP Code 81326.A post office called Hesperus has been in operation since 1891. The community takes its name from nearby Hesperus Mountain.Hesperus is located at 37°17′12″N 108°02′21″W / 37.28667°N 108.03917°W / 37.28667; -108.03917.